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Trequinsin hydrochloride

CAS No. 78416-81-6

Trequinsin hydrochloride( HL 725 )

Catalog No. M15958 CAS No. 78416-81-6

Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Trequinsin hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM).
  • Description
    Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM; reduces systemic blood pressure in both normotensive and hypertensive animal models.Hypertension Discontinued.
  • In Vitro
    Trequinsin hydrochloride exerts besides its cardiovascular and antihypertensive qualities very potent antiplatelet activities.Trequinsin hydrochloride is an efficacious agonist of [Ca2+]i. Cell Viability Assay Cell Line:Samples from healthy volunteer research donors with normal sperm motility parameters in agreement with World Health Organization 2010 criteria.Concentration:10 μM.Incubation Time:20 min.Result:Caused a concentration dependent increase in [Ca2+]i (EC50 = 6.4 μM [95% confidence interval (CI): 4.1-9.9 μM]).
  • In Vivo
    ——
  • Synonyms
    HL 725
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    PDE
  • Research Area
    Cardiovascular Disease
  • Indication
    Hypertension

Chemical Information

  • CAS Number
    78416-81-6
  • Formula Weight
    441.956
  • Molecular Formula
    C24H28ClN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (141.42 mM)
  • SMILES
    CC1=CC(=C(C(=C1)C)N=C2C=C3C4=CC(=C(C=C4CCN3C(=O)N2C)OC)OC)C.Cl
  • Chemical Name
    2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lal B, et al. J Med Chem. 1984 Nov;27(11):1470-80. 2. Ruppert D, et al. Life Sci. 1982 Nov 8;31(19):2037-43. 3. Darius H, et al. Br J Pharmacol. 1985 Mar;84(3):735-41. 4. Blaskó G, et al. Thromb Res. 1986 Jul 15;43(2):249-50.
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